Martha M. Coakley, the Democrat running for Senator Edward M. Kennedy’s seat in Massachusetts, had seemed so certain of winning the special election on Jan. 19 that she barely campaigned last month.

But the dynamic has changed in recent days. The news that two senior Democratic senators will retire this year in the face of bleak re-election prospects has created anxiety and, even in this bluest of states, a sense that the balance of power has shifted dramatically from just a year ago.

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